Best NFL prop bets for every Week 10 game: Saquon Barkley runs wild, the Justin Fields breakout continues, Justin Jefferson helps the Vikings cover in Buffalo

With Week 10 kicking off Thursday night, lots of fantasy football owners are waving the proverbial white flag and just going through the lineup-setting motions. Countless NFL teams’ fans have also given up hope in their real-life squad, knowing full well it won’t contend for a title, and in a sometimes-puzzling season, many bettors have understandably grown weary of betting moneylines, spreads, and over/unders. But one market that combines betting, fantasy, and fandom is the prop market, which provides fun and fast cash if you do your research and make the right plays. 

Player props, game props, and same-game parlays have become massively popular in recent years. Props are not only more fun to follow while watching a game, but they also seem to produce fewer “bad beats” than standard moneyline, spread, and over/under bets. You don’t always have to hitch your wagon to an entire team. In the world of props, you can simply bet on one player to produce (or fail to produce) at a certain level. 

Every Thursday, we scour BetMGM to pinpoint one potentially lucrative prop for each NFL game of the upcoming slate. It could be a player or team prop that we find the most interesting, most promising, or both. These prop wagers can involve offense, defense, special teams, or general scoring, but they all offer bettors distinct value based on stats and trends.

Let’s check out our favorite Week 10 props for every game and make some money in what should be another fun week of NFL action.

MORE WEEK 10 NFL BETTING: Odds, lines, spreads | Best bets

Best NFL prop bets for every Week 10 game

All prop bets are from BetMGM and Caesars

Falcons at Panthers (TNF): Cordarrelle Patterson OVER 54.5 rushing yards (-115 on BetMGM

Patterson returned from his knee injury last week and racked up 44 yards and two scores on 13 carries against the Chargers. Now he draws a Panthers defense that has allowed running backs to accrue the fourth-most rushing yards in the NFL. We still think Tyler Allgeier will be in the mix Thursday night, but Patterson should dominate the backfield touches. Even if he sees just 13 carries again, he should hit this OVER. He averages 5.4 yards per carry, and Carolina surrenders 4.5 yards per rushing attempt. By our calculations, that’s a baseline of between 58.5 and 70.2 yards. With an 82-percent chance of rain in Charlotte this evening, Patterson might hit this OVER by halftime. 

Seahawks vs. Buccaneers (Munich game): Leonard Fournette UNDER 45.5 rushing yards (-151 on Caesars)

Pretty much everything in Tampa Bay has been ugly this season, but Fournette’s rushing efficiency (or lack thereof) in recent weeks has been the ugliest. We get it, the Bucs’ offensive line is a shell of what it was when Tampa won Super Bowl LV, but Fournette has looked bad before and after contact, and every week we inch closer to Rachaad White’s time to shine. Just look at the two RBs’ numbers since Week 7:

Fournette vs. White: Production in Weeks 7, 8, and 9

Player Carries Rush Yards Avg.
Leonard Fournette 8 – 9 – 9 19 – 24 – 19 2.4
Rachaad White 6 – 4 – 8 24 – 19 – 27 3.9

It sure looks like the rookie would give the Bucs a better chance at rushing success, especially given Tracy Wolfson’s in-game reporting that Fournette was “extremely frustrated” at being replaced by White for a late first-half drive in Week 9. The rookie apparently had to console the fragile 6-foot, 228-pound veteran, assuring him “we need you.” No, Rachaad, the Bucs need you — and we all need to stay away from Fournette OVERs for the foreseeable future. 

Chiefs vs. Jaguars: Kansas City wins by 7-12 points (+400 on BetMGM)

No player props are listed for this one as of publication, so we’re going with a winning margin prop. The Chiefs have a point differential of +54 this season, which averages out to +6.75 points per game. Jacksonville has averaged just 20.3 points over its past three games, and Kansas City has averaged 28 over its past three. After the Chiefs barely eked out a 20-17 overtime win over Tennessee last week, we think they will have a solid game plan at home against one of the youngest squads in the NFL. I like what Doug Pederson has done with the Jags, but Trevor Lawrence can’t keep up with Mahomes at Arrowhead. I’ve got the Chiefs by between 7-10 points, which would be a mammoth hit at +400.

WEEK 10 NFL PICKS: Against the Spread | Moneyline

Browns at Dolphins: Nick Chubb OVER 84.5 rushing yards (-110 on BetMGM)

How quickly we forget how awesome Chubb has been this season. This over/under is laughable! Chubb sits behind only two-time rushing champ Derrick Henry for most rushing yards this year, and he ranks sixth in the NFL in yards per carry (5.6). He also averages 3.0 yards before contact and 2.6 yards after contact, which are elite numbers for a player whose offense basically revolves around him until Deshaun Watson’s suspension is over. Miami has allowed 117.4 rushing yards per game and just got rolled for 252 ground yards by Justin Fields and the Bears. Chubb should shine in South Beach this weekend. 

WEEK 10 NFL DFS: Best stacks | Best values

Giants vs. Texans: Saquon Barkley OVER 93.5 rushing yards (-115 on BetMGM)

It may feel like a trap, but it’s one of the more tempting potential traps of the season. Barkley has averaged 97.4 rushing yards per game this season, and the Texans have surrendered the most rushing yards in the NFL (180.6 yards per game). Houston has allowed 621 ground yards over the past three weeks, 219 of which came from Derrick Henry in Week 8. Don’t overthink this one. 

WEEK 10 DFS LINEUPS: DraftKings | FanDuel

Broncos at Titans: Russell Wilson OVER 226.5 passing yards (-117 on Caesars)

As Imagine Dragons once sang, “I’m just a sucker for pain.” Backing Russell Wilson in multiple props this season has been a torture chamber. However, he typically comes through with yardage props in plus-matchups. The Broncos are coming off a bye week and face a Titans secondary that has surrendered the second-most passing yards per game in the NFL (295.5). Wilson has thrown for at least 237 yards in three of Denver’s past four matchups, two of which were on the road. It’s hard to be confident about Mr. Limited, but we think he can hit this one fairly easily. 

Saints at Steelers: Chris Olave anytime TD scorer (+185 on Caesars)

The Steelers rocking a solid pass defense is a thing of the past, my friends. A.J. Brown obliterated Pittsburgh on Hallow’s Eve, catching six-of-10 Jalen Hurts targets for 156 yards and three TDs. Now Mike Tomlin’s guys have to contain top rookie wideout Chris Olave? Good luck. If New Orleans scores through the air, it will be thanks to this kid. You might say Juwan Johnson, but the Steelers have actually been pretty good against tight ends (44.5 yards per game, one TD allowed all season). It’s the wideouts that have killed them, as Pittsburgh has surrendered a league-high 13 TD receptions to receivers. 

Lions at Bears: Justin Fields OVER 58.5 rushing yards and Darnell Mooney OVER 42.5 receiving yards (+255 on Caesars Same Game Parlay)

The Bears have finally unlocked the cheat code that is Fields, and the key has been his legs. The second-year QB has attempted 49 rushes over the past four weeks, resulting in 408 yards and three TDs. My calculator tells me that’s an average of 8.3 yards per carry, a pretty sweet mark considering Chicago has played Dallas, New England, Miami, and Washington over the past month. Now da Bears welcome the division-rival Lions, who have allowed the second-most rushing yards in the NFL and the fourth-most rushing yards to the QB position. Oh, and let’s not forget that Fields’ legs have also opened up opportunities for his arm. Mooney has enjoyed easily his best stretch of the season since Fields’ breakout, catching 22-of-31 passes for 234 yards and a score. Back to the calculator, that looks like 58.5 yards per game, and Detroit has allowed the fourth-most total passing yards this season. The Lions are the gift that keeps on giving — cash in on this SGP before they pull it! 

Vikings at Bills: Vikings +6.5 alternate handicap (-165 on BetMGM)

So much mystery surrounds this game. Will Josh Allen’s UCL injury sideline him, or will one-time Viking Case Keenum make the start against his former squad? Too much volatility here for me, so we’ll avoid all player props and instead play it super safe by buying some points for the underdog. If Allen doesn’t play, this is a layup. Even if he does play, Buffalo just lost to the Jets. Do we expect a dinged-up Allen to lead the Bills to a blowout over a 7-1 team? I’d imagine Justin Jefferson and Dalvin Cook would shake their heads “no,” and I would tend to agree. 

Raiders vs. Colts: Outcome of 1st Vegas drive = Punt (-140 on Caesars)

The Raiders have punted on each of their past two opening drives (against the Jaguars and Saints), and now they face the fifth-best third-down defense in the NFL. Oh, and both tight end Darren Waller (hamstring) and slot receiver Hunter Renfrow (oblique) hit the IR this week, and Josh Jacobs has been held to 55 rushing yards per game over the past two games. Yeah, we’re all-in on another exciting opening-drive punt from the brilliant offense of Josh McDaniels. 

Cowboys vs. Packers: Cowboys moneyline + OVER 31.5 total points (-130 on BetMGM’s win/total page)

I love the Cowboys at home against the banged-up bruised egos of the Packers, and 31.5 seems like a very attainable number of points in a Dak Prescott vs. Aaron Rodgers duel. The Cowboys have been weakest against the run, allowing the ninth-most rushing yards in the NFL, and running is about all Green Bay can do right now. The Packers have allowed 27 points in three of their past five games, so this is a very doable double-prop. 

Cardinals at Rams: Cardinals winning margin 1-6 (+325 on BetMGM)

I expect an upset here, if you can even call it an upset considering this should probably be listed as a pick ’em. The Rams offense has been in shambles all season — from the offensive line to the running game to the ancillary receivers beyond Cooper Kupp — and defenses with any semblance of a pass-rush have been feasting. Add to that a Matthew Stafford concussion, and L.A.’s chances of winning look murky, at best. Of course, the Cardinals also list Kyler Murray as questionable and “day-to-day” with a hamstring, so there’s that, but honestly, even if we’re in for a Colt McCoy-John Wolford showdown, my money will be on Arizona eking one out. The Cardinals have superior offensive depth with DeAndre Hopkins and Rondale Moore out wide, Zach Ertz over the middle, and James Conner and Eno Benjamin in the backfield. The Super Bowl hangover worsens this week for the Rams, with or without Stafford. 

49ers vs. Chargers: San Francisco OVER 25.5 points (-151 on Caesars)

Unlike the Rams, the 49ers have had an enjoyable couple of weeks. They beat out L.A. in the Christian McCaffrey trade sweepstakes, and his impact on Jimmy G and the Niners offense has been immediate and immense. They crushed the Rams 31-14 in Week 8, and then got some much-needed rest in their Week 9 bye week. Now they face a Chargers team that has been loading up the injury report on both sides of the ball. Top Bolts cornerback J.C. Jackson (knee) is out for the season, top pass-rusher Joey Bosa (groin) is still rehabbing from surgery, and receivers Keenan Allen (hamstring) and Mike Williams (ankle) likely remain out this weekend, as well. Justin Herbert has taken a step back this season, so I just don’t see Los Angeles standing much of a chance in this one. If the Niners can put 31 on the Rams before their bye week, they might be able to put a 40-burger on the broken-down Bolts. 

Eagles vs. Commanders: Eagles UNDER 28.5 total points (-135 on BetMGM)

The Eagles are flying high at 8-0, while the Commanders are, well, losing command at 4-5. But most of Washington’s woes have been on the offensive side of the ball. Ron Rivera’s defense has actually played pretty well over the past five weeks. The Commanders haven’t allowed more than 21 points in a game since Oct. 2, and they have forced six turnovers over the past four games. I’m not suggesting Washington has even a semblance of a chance to pull off the upset, even on Monday Night Football (Jalen Hurts is one of the exceptions of the prime-time underdog rule — read more here). However, I do think Jalen Hurts, A.J. Brown, Miles Sanders, and company will be held to under 29 points. Plain and simple, Philly won’t need that many points, and Washington’s feisty D won’t roll over, especially if Chase Young (knee) makes his season debut. I could easily see this game finishing 24-17, and not just because the Eagles haven’t allowed more than 17 points in over five weeks. 

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